长期专注于细胞生长因子类蛋白药理机制及新药研发，聚焦“细胞生长因子FGFs与代谢性肝病”，从临床发现FGFs是肝脏代谢紊乱高敏性响应因子的基础之上，深入探索FGFs启动特异性信号转导，而发挥调控肝脏脂质和胆汁酸稳态的独特生物学功能和药理机制，为基于FGFs的代谢性肝病治疗靶标发现和药物研发提供了新思路和新策略。以通讯或第一（含共同）作者在Cell Metabolism, Nature Communications (2篇), Hepatology (2篇), Kidney International等高质量SCI期刊发表研究论文10余篇；主持国家自然科学基金委面上项目、青年项目等省部级项目。
入选浙江省 “万人计划”青年拔尖人才、浙江省“高校领军人才培养计划”和温州市“瓯越海智计划”。
1. 专业研究方向：细胞生长因子类蛋白药理机制及新药研发
2. 科研项目：
1）国家自然科学基金，面上项目， 2024-01至2027-12，在研，主持
2）国家自然科学基金，青年项目， 2021-01至2023-12，已结题，主持
3）浙江省自然科学基金，重点项目， 2023-01至2025-12，在研，主持
4）博士后科学基金面上项目，2019M652254，结题，主持
5）浙江省自然科学基金，青年项目2015-01至2017-12，结题，主持
3. 发表论文
(#Co-first authors, *Corresponding author)
1.Song L*,#, Hou Y#, Xu D#, Dai X, Luo J, Liu Y, Huang Z, Yang M, Chen J, Yue Hu, Chen C, Tang Y, Rao Z, Ma J, Zheng M, Shi K, Cai C, Lu M, Tang R, Ma X, Xie C, Luo Y, Li X*, Huang Z*. Hepatic FXR-FGF4 is required for bile acid homeostasis via a FGFR4-LRH-1 signal node under cholestatic stress. Cell Metabolism. 2024, Oct 4:S1550-4131(24)00372-3.
2.Song L#, Wang L#, Hou Y#, Zhou J, Chen C, Ye X, Dong W, Gao H, Liu Y, Qiao G, Pan T, Chen Q, Cao Y, Hu F, Rao Z, Chen Y, Han Y, Zheng M, Luo Y, Li X*, Chen Y*, Huang Z*. FGF4 protects the liver from nonalcoholic fatty liver disease by activating the AMP-activated protein kinase-Caspase 6 signal axis. Hepatology. 2022 Oct;76(4):1105-1120.
3.Song L#, Liu Z#, Hu HH, Yang Y, Li TY, Lin ZZ, Ye J, Chen J, Huang X, Liu DT, Zhou J, Shi Y, Zhao H, Xie C, Chen L, Song E, Lin SY, Lin SC*. Proto-oncogene Src links lipogenesis via lipin-1 to breast cancer malignancy. Nature Communications. 2020 Nov 17;11(1):5842.
4.Wang L#, Dong W#, Gao H#, Chen C#, Liang S, Ye X, Yi Liu Y, Hou Y, Lei Fan L, Pan T, Wang Z*, Chen Y*, Luo Y*, Song L*. A non-mitogenic FGF4 analog alleviates non-alcoholic steatohepatitis through an AMPK-dependent pathway. Biochim Biophys Acta Mol Basis Dis. 2022 Dec 1;1868(12):166560.
5.Li TY#, Song L#, Sun Y#, Li J, Yi C, Lam SM, Xu D, Zhou L, Li X, Yang Y, Zhang CS, Xie C, Huang X, Shui G, Lin SY, Reue K, Lin SC*. Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate. Nature Communications. 2018 May 15;9(1):1916.
6.Sun Y#, Li TY#, Song L#, Zhang C, Li J, Lin ZZ, Lin SC, Lin SY*. Liver-specific deficiency of unc-51 like kinase 1 and 2 protects mice from acetaminophen-induced liver injury. Hepatology. 2018 Jun;67(6):2397-2413.
7.Liang G#, Song L#, Chen Z#, Qian Y, Xie J, Zhao L, Lin Q, Zhu G, Tan Y, Li X, Mohammadi M*, Huang Z*. Fibroblast growth factor 1 ameliorates diabetic nephropathy by anti-inflammatory mechanism. Kidney International. 2018 Jan; 93(1), 95-109.
8.Song L#, Zhu Y#, Wang H#, Belov AA, Niu J, Shi L, Xie Y, Ye C, Li X*, Huang Z*. A solid-phase PEGylation strategy for protein therapeutics using a potent FGF21 analog. Biomaterials, 2014; 35(19): 5206-5212.
Song L, Huang Z, Chen Y, Li H, Jiang C*, Li X*. High-efficiency production of bioactive recombinant human fibroblast growth factor 18 in Escherichia coli and its effects on hair follicle growth. Appl Microbiol Biotechnol, 2014; 98(2): 695-704.