诸葛德力,校聘副研究员,以第一作者或并列第一作者在Small、 J Control Release、 Adv Healthc Mater、ACS NANO等本学科权威期刊发表SCI论文10余篇,授权发明专利2项,主持包括浙江省自然科学基金、温州市科技局项目3项。
工作经历:
2023.06-至今,温州医科大学,校聘副研究员
研究方向:
1.基于孔形成蛋白的生物医学应用;
2.光、声驱动的抗菌与抗肿瘤研究;
3.靶向微/纳米药物递送系统。
主持基金:
1.浙江省自然科学基金青年项目(LQ24C080002),2024.1.1-2026.12.31,主持,在研。
2.温州市科技局一般项目(Y2023181),2024.1.1-2025.12.31,主持,在研。
3.温州医科大学科研业务费(KYYW202334),2024.1.1-2026.12.31,主持,在研。
代表性论文:
1.Zhuge DL, Chen MC, Yang XW et al. Toxin-Enabled "On-Demand" Liposomes for Enhanced Phototherapy to Treat and Protect against Methicillin-Resistant Staphylococcus aureus Infection. Small. 2022 Sep;18(35): e2203292.
2.Zhuge DL, Li L, Wang HN, et al. Bacterial Toxin-Responsive Biomimetic Nanobubbles for Precision Photodynamic Therapy against Bacterial Infections. Adv Healthc Mater. 2022 Sep;11(18) :e2200698.
3.ZhuGe DL, Wang LF, Chen R, et al. Cross-linked nanoparticles of silk fibroin with proanthocyanidins as a promising vehicle of indocyanine green for photo-thermal therapy of glioma. Artif Cells Nanomed Biotechnol. 2019 Dec;47(1): 4293-4304.
4.ZhuGe DL, Javaid HMA, Sahar NE et al. Fibroblast growth factor 2 exacerbates inflammation in adipocytes through NLRP3 inflammasome activation. Arch Pharm Res. 2020 Dec;43(12): 1311-1324.
5.Zhao YZ, ZhuGe DL, Tong MQ, et al. Ulcerative colitis-specific delivery of keratinocyte growth factor by neutrophils-simulated liposomes facilitates the morphologic and functional recovery of the damaged colon through alleviating the inflammation. J Control Release. 2019 Apr 10;299: 90-106.
6.Xu HL, ZhuGe DL, Chen PP, et al. Silk fibroin nanoparticles dyeing indocyanine green for imaging-guided photo-thermal therapy of glioblastoma. Drug Deliv. 2018 Nov;25(1):364-375.
7.Jiang Q, Chen MC, Yang XW, Zhuge DL, et al. Doxorubicin Detoxification in Healthy Organs Improves Tolerability to High Drug Doses for Enhanced Antitumor Therapy. ACS Nano. 2023 Apr 25;17(8): 7705-7720.