专注于神经疾病之间的关联性研究，聚焦“阿尔茨海默病的分子致病机制研究”，同时研究“自闭症的致病风险基因”，探索相关风险基因在以上疾病中的致病机理，探索临床转化的价值，致力于为阿尔茨海默病和自闭症的治疗靶标发现和药物研发提供新思路和新策略。以第一（含共同）作者在Science, Journal of Clinical Investigation (2篇), STTT (1篇)等高质量SCI期刊发表研究论文7篇；主持1项国家自然科学基金委青年项目（在研）和1项中国博士后面上项目（结题），参与1项重大项目（在研）。

1. 专业研究方向：阿尔茨海默病和自闭症的致病机制研究

2. 科研项目：

1）国家自然科学基金，青年项目， 2024-01至2026-12，在研，主持

2）中国博士后科学基金面上项目，2019M652254，结题，主持

3）国家自然科学基金，重点项目， 2023-01至2027-12，在研，参与

3. 发表论文

(^#Co-first authors, *Corresponding author)

1. Mengen Xing and Weihong Song. Engineering Aβ-antibody for safer and more effective Alzheimer’s immunotherapy, Science, 2025. (Perspective, under evaluation)

2. Mengen Xing#; Wanqi Chen#; Yachen Ji; Weihong Song. SLC44A2-mediated phenotypic switch of vascular smooth muscle cells contributes to aortic aneurysm, The Journal of Clinical Investigation, 2024. (First author)

3. Qing Zhang#; Mengen Xing#; Bao Zhengkai#; Lu Xu; Yang Bai; Wanqi Chen; Wenhao Pan; Fang Cai; Qunxian Wang; Shipeng Guo; Jing Zhang; Zhe Wang; Yili Wu; Yun Zhang; Jia-Da Li; Weihong Song. Contactin-associated protein-like 2 (CNTNAP2) mutations impair the essential α-secretase cleavages, leading to autism-like phenotypes, Signal Transduction and Targeted Therapy, 2024. (Co-first author)

4. Mengen Xing#; Qing Zhang#; Weihong Song. GIGYF1-disturbed IGF-1R recycling: a potential contributor to autism spectrum disorder pathogenesis, The Journal of Clinical Investigation, 2022. (First author)

5. Keenan Sterling#; Mengen Xing#; Weihong Song; Do Systemic Infections Contribute to the Pathogenesis of Dementia, Neuroscience Bulletin, 2021. (Co-first author)

6. Mengen Xing#; Na Yang; Ning Jiang; Dawei Wang; Xiaoyu Sang; Ying Feng; Ran Chen; Xinyi Wang; Qijun Chen; A Sialic Acid-Binding Protein SABP1 of Toxoplasma gondii Mediates Host Cell Attachment and Invasion, The Journal of Infectious Diseases, 2020. (First author)

7. Na Yang#; Mengen Xing#; Yingying Ding; Dawei Wang; Xiaogai Guo; Xiaoyu Sang; Jiaqi Li; Chenghuan Li; Yanhu Wang; Ying Feng; Ran Chen; Xinyi Wang; Ning Jiang; Qijun Chen; The Putative TCP-1 Chaperonin Is an Important Player Involved in Sialic Acid-Dependent Host Cell Invasion by Toxoplasma gondii, Frontiers in Microbiology, 2020. (Co-first author)

E-mail：simonxing@wmu.edu.cn

通讯地址：温州医科大学生物医药科研大楼北楼17楼