长期专注于肺纤维化、肺动脉高压及肺损伤修复机制研究。于德国吉森大学获博士学位（2017-2022），以第一/通讯作者在《Nature Communications》（IF=16.6）、《European Respiratory Journal》（IF=17）等期刊发表论文27篇，系统阐释GLI1+细胞在肺血管重塑与再生中的核心作用，并提出“脂成纤维细胞-肌成纤维细胞可逆转化”理论，为肺疾病治疗提供新靶点。主持国家自然科学基金青年项目、浙江省自然科学基金等课题，深度参与德国SFB CRC1213国际合作研究。成果获德国心肺研究中心青年学者奖（2022）等多项奖项，推动肺病精准治疗领域理论创新。
入选2025年浙江省领军人才青年项目千人名单。
1. 专业研究方向：肺纤维化、肺动脉高压及肺损伤修复机制。
2. 科研项目：
1）国家自然科学基金，面上项目， 2019-01至2022-12，已结题，参与
2）国家自然科学基金，青年项目， 2025-01至2027-12，在研，主持
3）浙江省自然科学基金，青年项目， 2024-01至2026-12，在研，主持
1. Chu, X., Kheirollahi.V, A. I. Vazquez-Armendariz, Hadzic. S, Lingampally. A, Pak. O, CrnKovic. S, Heiner. M, Kraut. S, Soothedih. L, Khadim. Ali, Günther. S, Koepke. J, Valente. G, Braun. T, Samakovlis. C, Alexopoulos. I, Mario. L, Chao. CM, Herold. S, Seeger. W, Kwaspiszewska. G, Weissmann. N, Huang. XY, Li. Xk, El Agha. E, and Bellusci. S. (2023)“GLI1+ cells are key contributors to neo-muscularization in hypoxia-induced pulmonary hypertension.” (IF=16.5, JCR 分区 Q1, 中科院 top 期刊)
2. Chu, X., A. Lingampally, A. Moiseenko, V. Kheirollahi, A. I. Vazquez-Armendariz, S. Günther, K. Lebrigand, M. Truchi, S. Herold, B. Mari, J. S. Zhang, S. Bellusci*, E. E. Agha* (2022). “GLI1+ cells are a source of repair-supportive mesenchymal cells (RSMCs) during airway epithelial regeneration.” CMLS. （IF=6.2 ， JCR 分区 Q1 ，中科院 top 期刊）
3. Chu, X., S. Taghizadeh, A. I. Vazquez-Armendariz, S. Herold, L. Chong, C. Chen, J. S. Zhang, E. El Agha and S. Bellusci (2021)."Validation of a Novel Fgf10 (Cre-ERT2) Knock-in Mouse Line Targeting FGF10(Pos) Cells Postnatally." Front Cell Dev Biol 9:671841. （ IF=6.081 ， JCR 分区 Q1)
4. Chu, X., C. Chen, C. Chen, J. S. Zhang, S. Bellusci and X. Li (2020). "Evidence for lung repair and regeneration in humans: key stem cells and therapeutic functions of fibroblast growth factors." Front Med 14(3): 262-272.（IF=3.9 ，JCR分区Q2）
5. Chu, X., N. Ahmadvand, J. S. Zhang, W. Seeger, S. Bellusci and E. El Agha (2021). “Evidence for multiple origins of de novo formed vascular smooth muscle cells in pulmonary hypertension: Challenging the dominant model of pre-existing smooth muscle expansion.”Int. J. Environ. Res. Public Health 18.
6. A. Noori, I. Alexopoulos, X. Shi, E. V. Pacheco, J. Koepke, C. X, I. Salvig, C. Samakovlis, M. Bartkuhn, T. Procida, T. Braun, Chu, X., S.Bellusci* (2025). （ready to submit to European Respiratory Journal）
7. Shahriari Felordi, M., A. Khadim, A. Lingampally, A. I. Vazquez-Armendariz, T. Procida-Kowalski, S. Hadzic, I. Alexopoulos, A.Günther, N. Weissmann, M. Bartkuhn, W. Seeger, S. Herold, S. Bellusci, X. Chu#, E. E. Agha# "A WNT-inhibitory adventitial niche promotes airway epithelial regeneration." (submitted to Nature Cell Biology).
8. Soothedih, L., X. Shi, A. Khadim, A. Lingampally, A. I. Vazquez-Armendariz, S. Hadzic, O. Pak, S. Crnkovic, S. Kraut, J. Koepke, G.Valente, C. Samakovlis, I. Alexopoulos, C. M. Chao, S. Herold, W. Seeger, X. Huang, N. Weissmann, X. Li#, S. Bellusci#, E.E.Agha#, and X. Chu# "Differential labeling of ACTA2+ cells in hypoxia-induced hypertension reveals a novel population existence contributing to the neo-muscularization." (ready to submit to Circulation).
9. Zabihi M, Shahriari Felordi M, Lingampally A, Bellusci S, Chu X, El Agha E. Understanding myofibroblast origin in the fibrotic lung.Chinese Medical Journal Pulmonary and Critical Care Medicine. 2024; Available from:https://www.sciencedirect.com/science/article/pii/S277255882400052. (IF=7.5)
10. Lingampally A, Truchi M, Shi X, Zhou Y, Vasquez-Pacheco E, Panagiotidis G-D, Hadzic S, Koepke J, Vazquez-Armendariz AI, Herold S, Samakovlis C, Cabrera-Fuentes HA, Chu X, Seeger W, Zhang J-S, El Agha E, Mari B, Bellusci S, Chen C. Unraveling Alveolar Fibroblast and Activated Myofibroblast Heterogeneity and Differentiation Trajectories During Lung Fibrosis Development and Resolution in Young and Old Mice. Aging Cell. n/a: e14503. (IF=8, JCR 分区 Q1 ，中科院 top 期刊)
11. Kheirollahi, V., R. M. Wasnick, V. Biasin, A. I. Vazquez-Armendariz, X. Chu, A. Moiseenko, A. Weiss, J. Wilhelm, J. S. Zhang, G.Kwapiszewska, S. Herold, R. T. Schermuly, B. Mari, X. Li, W. Seeger, A. Günther, S. Bellusci and E. El Agha (2019). "Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis." Nat Commun 10(1): 2987.（ IF=16.6 ， JCR 分区 Q1 ，中科院 top 期刊）
12. Khadim A, Kiliaris G, Vazquez-Armendariz AI, Procida-Kowalski T, Glaser D, Bartkuhn M, Malik T, Chu X, Moiseenko A, Kuznetsova I, Ahmadvand N, Lingampally A, Hadzic S, Alexopoulos I, Chen Y, Günther A, Behr J, Neumann J, Schiller HB, Li X, Weissmann N, Braun T, Seeger W, Wygrecka M, Morty RE, Herold S, Agha EE. Myofibroblasts emerge during alveolar regeneration following influenza-virus-induced lung injury. Cell Reports [Internet]. 2025; 44.Available from:https://www.cell.com/cellreports/abstract/S2211-1247(25)00019-1.(IF=7.5, JCR 分区 Q1，中科院 top 期刊)
13. LingampallyA, Truchi M, Mauduit O, Delcroix V, Vasquez-Pacheco E, Gautier-Isola M, Chu X, KhadimA, Chao C-M, Zabihi M, Taghizadeh S, Rivetti S, Marega M, Moiseenko A, Hadzic S, Vazquez-Armendariz AI, Herold S, Günther S, Millar-Büchner P, Koepke J, Samakovlis C, Wilhelm J, Bartkuhn M, Braun T, Weissmann N, Zhang J, Wygrecka M, Makarenkova HP, Günther A, Seeger W, Chen C, El Agha E, Mari B, Bellusci S. Evidence for a lipofibroblast-to- Cthrc1 + myofibroblast reversible switch during the development and resolution of lung fibrosis in young mice. Eur Respir J. 2024;2300482. （ IF=17 ， JCR 分区 Q1 ，中科院 top 期刊）
14. Feng, B., Y. Cao, S. Chen, X. Chu, Y. Chu and S. Chakrabarti (2016). "miR-200b Mediates Endothelial-to-Mesenchymal Transition in Diabetic Cardiomyopathy." Diabetes 65(3): 768-779. （ IF=7.7 ， JCR 分区 Q1 ，中科院 top 期刊）
E-mail：chuxuran@gmail.com
通讯地址：温州医科大学生物医药科研大楼5楼/瓯江实验室5号楼3016C