长期致力于神经修复与慢性疼痛的分子机制解析与治疗靶点开发，通过整合单细胞多组学测序（snRNA-seq、snATAC-seq）、转基因小鼠谱系示踪、神经病理性疼痛模型等前沿技术，系统研究疼痛相关神经细胞的异质性、动态互作及表观遗传调控网络。近五年以第一作者发表SCI论文4篇（其中中科院一区2篇），在审论文1篇（Nature Communications），在投1篇（Glia）。主持完成国际合作项目2项、国家自然科学基金1项，获国家专利2项。

专业研究方向：周围神经病变与疼痛机制及干预策略

1. 国内科研项目：

国家自然科学基金，青年项目，2022-01至2024-12，已结题，主持。

2. 发表论文

(^#Co-first authors, *Corresponding author)

1. Prach Techameena#, Xiaona Feng#, Kaiwen Zhang and Saida Hadjab*. The single-cell transcriptomic atlas iPain identifies senescence of nociceptors as a therapeutical target for chronic pain treatment. Nat Commun. 2024 Oct 4;15(1):8585.

2. Xiaona Feng#, Prach Techameena#, Kaiwen Zhang, Rolen Quadros, Csaba Adori, Francois lallemend, Channabasavaiah Gurumurthy and Saida Hadjab*. Rnase4 functions in nociceptor-mediated nerve homeostasis. (Under peer review, Nat Commun.)

3. Xiaona Feng, Xuejun Song*, Makoto Tominaga*. Schwann cell TRPV4 promote myelin plasticity in peripheral nervous system. (Manuscript).

4. Xiaona Feng, Yasunori Takayama, Nobuhiko Ohno, Hirosato Kanda, Yi Dai, Takaaki Sokabe, Makoto Tominaga*. Increased TRPV4 expression in non-myelinating Schwann cells is associated with demyelination after sciatic nerve injury. Commun Biol., 2020 Nov 27; 3(1):716.

5. Xiaona Feng, Donglin Xiong#, Jie Li, Lizu Xiao*, Weijiao Xie* and Yunhai Qiu*. Direct inhibition of microglia activation by pretreatment with Botulinum Neurotoxin A for the prevention of neuropathic pain. Front Neurosci. 2021 Dec 7;15:760403.

6. Xiaona Feng, Xuejun Song and Makoto Tominaga*. Physiological Significance of TRPV4 Channels in Non-Myelinating Schwann cells. Int J Phys Med Rehabil, 2021 Feb 17, Vol.9 Iss.01 No:1000588

3. 知识产权申请情况：

E-mail：xn.feng@wmu.edu.cn

通讯地址：温州医科大学生物医药科研大楼北楼17楼