长期专注于基于细胞生长因子类蛋白的神经损伤药物设计及机制研究，聚焦“细胞生长因子FGFs与脊髓损伤”，开展生长因子、干细胞、外泌体等与功能性生物材料结合在脊髓损伤修复领域的应用和机制研究。 近期在Nature Nanotechnology, Nature Communications等发表了等高影响力期刊发表论文10余篇；主持浙江省优秀青年基金项目1项，参与国家自然科学基金项目3项，科技部项目1项，入选温州市“瓯越英才”青年类人才项目。

专业研究方向：基于细胞生长因子类蛋白的神经损伤药物设计及机制研究

发表论文：

第一/共同第一作者(^# First Authors)；通讯作者( *First Authors)

Zuo Yanming^#, Ye Jingjia ^#, Wang Xuhua, et al. Controlled delivery of a neurotransmitter-agonist conjugate for functional recovery after severe spinal cord injury， Nature Nanotechnology, 2023,18:1230-1240

Fang Ao ^#, Wang Yifan ^# Guan Naiyu ^#, Yanming Zuo^#, Wang Xuhua,et al. Porous microneedle patch with sustained MSC- EV delivery mitigates severe spinal cord injury. Nature Communication, 2023，14:1

Feng Zhiyi#，Zuo Yanming#*（通讯作者，共同一作）, Shen Jiamen, Zhao Qian, Cao Zhi Qiang, Li Xiaokun*, Wang Zhouguang*. Bioengineering microspheres regulating mesenchymal stem cell fate accelerate spinal cord injury therapeutics. Nano Today, 2025; 61,102574.

Zuo Yanming, Ying Y, Huang Z, Shen J, Li X, Wang Z. Reactive oxygen species targeted biomaterials for spinal cord injury therapy. Brain-X. 2023;1:e32.

Li Xiaodan ^#, Zuo Yanming ^#, Lin Xurong ^#, Wang Xuhua et al. Develop targeted protein drug carriers through a high-throughput screening platform and rational design，Advanced Healthcare Materials, 2401793.

Zuo Yanming^#, Yan Xu^#, Xue Jinzhe, Guo Luyin, Lu Yang, Tao He, et al.Enzyme-Responsive Ag Nanoparticle Assemblies in Targeting Antibacterial against Methicillin-Resistant Staphylococcus Aureus[J]. ACS Applied Materials & Interfaces, 2020,12, 4, 4333-4342

参与作者

Binjie Guo, Hanyu Zheng, Haohan Jiang, Xiaodan Li, Naiyu Guan, Yanming Zuo, Yicheng Zhang, Hengfu Yang, Xuhua Wang, Enhanced compound-protein binding affinity prediction by representing protein multimodal information via a coevolutionary strategy, Briefings in Bioinformatics, 2023;, bbac628, https://doi.org/10.1093/bib/bbac628

Lingmin Lin, Zewei He, Tianfang Zhang, Yanming Zuo, Zeinab Abdelrahman, Xiangfeng Chen, Feihong Chen, Zhongchao Wei, Ke Si, Wei Gong, Xuhua Wang, Sailing He, and Zuobing Chen . A biocompatible two-photon absorbing fluorescent mitochondrial probe for deep in vivo bioimaging[J]. Journal of Materials Chemistry B, 2022, 10, 887

Liu Jianhua, Wais, U., Zuo Yanming, Xiang Yu, Tao He, Zhang Haifei, et al. Unimolecular branched block copolymer nanoparticles in methanol for the preparation of poorly water-soluble drug nanoparticles[J]. Journal of Materials Chemistry B, 2017, 5(3): 423-427.

Wais, U., Jackson, A. W., Zuo Yanming, Xiang Yu, Tao He, Zhang Haifei. Drug nanoparticles by emulsion-freeze-drying via the employment of branched block copolymer nanoparticles[J].Journal of Controlled Release, 2016, 222: 141-150.

Ying Xinwang#, Xie Qingfeng#, Zhao Yanfang#, Shen Jiamen#, Huang Junqing, Feng Zhiyi, Chu Liuxi, Xu Junpeng, Jiang Dawei, Wu Ping, Zuo Yanming, Li Shengcun, Jiang Chang*, Li Xiaokun*, Wang Zhouguang*. Exercise therapy facilitates neural remodeling and functional recovery post-spinal cord injury via PKA/CREB signaling pathway modulation in rats. Burns Trauma. 2025; Doi: 10.1093/burnst/tkae058.

主持及参与课题 (课题负责人或参与者)

1. 浙江省自然科学基金委员会,优秀青年自然科学基金项目，LZYQ25H30002，自驱动纳米发电机系统递送FGF21时空调控LRP1重塑线粒体转运治疗脊髓损伤机制研究，2025-01-01 至 2027-12-31，48万元, 在研，项目主持人

2. 国家自然科学基金委员会, 面上项目, 82372134, 新型小胶质细胞调控炎症微环境促进脊髓损伤修复的作用及机制研究, 2024-01-01 至 2027-12-31, 48万元, 在研，项目核心参与者

3. 国家自然科学基金委员会, 面上项目, 82371374, 促进脊髓神经再生及发挥功能的药物及作用机制研究, 2024-01-01 至 2027-12-31, 49万元, 在研, 项目核心参与者

4. 国家自然科学基金委员会, 面上项目, 21574035, 可特定解离并高效入胞的高靶向聚合物纳米磁共振造影剂, 2016-01-01 至 2019-12-31, 65万元, 完成，项目核心参与者

5. 国家科技部, 科技创新2030——脑科学与类脑研究, 2021ZD0200400, 脑机交互计算融合研究平台——非侵入式脑机融合应用, 2021-12 至 2026-12, 60万元, 在研, 项目核心参与者

E-mail：zuoyanming@wmu.edu.cn

通讯地址：温州医科大学生物医药科研大楼南楼10楼